A new study has found that GLP-1 medications performed better than metformin in managing
blood sugar levels and reducing the risk of type 2 diabetes among people with prediabetes and
obesity.

The research analysed health data from 256,492 adults with prediabetes and obesity. The
findings were released by the American Heart Association (AHA) on November 2, ahead of its
Scientific Sessions 2026. The event was held in Chicago from November 6 to 9.
According to the study, people taking GLP-1 medications were more likely to return to normal
blood sugar levels compared with those taking metformin.

Over the three-year study period, patients using GLP-1 medications had a 50 percent higher
chance of reversing high blood sugar levels to normal. They also had a 31 percent lower risk of
developing type 2 diabetes.

The analysis also reported better health outcomes among GLP-1 users. Their risk of death from
any cause was 41 percent lower than that of patients taking metformin.

The study also found fewer cases of serious heart-related problems among people using GLP-1
medications. They had 15 percent fewer heart attacks, 20 percent fewer strokes and 25 percent
fewer cases of heart failure. The analysis also reported an 8 percent reduction in atrial fibrillation
cases.

Meanwhile, demand for weight management treatments is also increasing. According to TELUS
Health’s 2026 Drug Data Trends and National Benchmarks Report, weight management moved
up six positions to rank 11th among Canadian private drug plan categories.

Spending on weight management treatments increased by 61 percent in 2025. This followed a
104 percent rise in 2024. These treatments accounted for 2.5 percent of total eligible drug
spending. Diabetes medications remained the largest private drug plan category, representing
13.2 percent of total spending.

The findings highlight the growing role of GLP-1 medications in weight management and blood
sugar control. However, the study was based on a matched analysis, so the results show
differences between the treatment groups rather than proving that the medications directly
caused every improvement. Patients should consult healthcare professionals before starting or
changing any medication.

Source: Released by the American Heart Association and data from TELUS Health.

Fatima Khan